Stem Cells Derived from Fat
Circa 2019 :3
Multipotent stem cells are essential to regenerative medicine, and the deployment strategies that go with it. By locating an abundant supply of adult autologous stem cells, we can circumvent the ethical and immunological dilemmas associated with embryologic stem cell research. These cells are known as mesenchymal (MSC) stem cells. We describe adipose as a unique MSC source because of its abundance, redundancy and availability. Lipoaspirates are minimally processed into a cell-dense, heterogeneous isolate called the stromal-vascular fraction (SVF), which is composed of terminally-differentiated vessel-associated cells and putative progenitor cell lines. These cells were expanded and cultured to produce a dynamic cell-line called adipose derived stromal (ASC) cells. SVF and ASC cells are administered via standard clinical routes, including topical application and local injection, in clinical translational studies for cardiovascular ischemia and neurological injury. These clinical applications raise concerns about safety, specifically in relation to administration, tumor growth enhancement, and sequestration. To realize the potential of SVF and ASC in regenerative medicine, further studies are required.
Source:
https://www.sciencedirect.com/science/article/pii/B9780128098806000199
