AI combined with CRISPR precisely regulates gene expression
According to a new study published in Nature Biotechnology, artificial intelligence can predict the on- and off-target behavior of CRISPR tools which target RNA rather than DNA.
Researchers at New York University and Columbia University have combined a deep-learning model with CRISPR screens in order to control gene expression in different ways. For example, flicking a switch can turn them completely off or using a dimming knob to reduce their activity. These precise gene controls may be used to create new CRISPR-based treatments.
CRISPR, a gene-editing technology, has many applications in biomedicine. It can be used to treat sickle cell disease or create mustard greens that are more tasty. It works most often by targeting DNA with an enzyme called Cas9. Scientists have discovered a new type of CRISPR in recent years that targets RNA instead using an enzyme named Cas13.
Source:
https://phys.org/news/2023-06-ai-combined-crispr-precisely-gene.html
