Alteration of gut bacteria may be an early sign of Alzheimer’s
Researchers at Washington University School of Medicine, St Louis, have conducted a new study that examined the composition of the gut bacteria of individuals who are in the early stages of Alzheimer’s. This research was published in Science Translational Medicine. It not only identifies possible indicators of increased dementia risk but also provides prospects for developing preventive treatments that alter the microbiome to combat cognitive decline.
Longevity. Technology: Scientists have previously noted differences between the gut microbiomes in individuals with symptomatic Alzheimer’s and their healthy counterparts. The current study, however, goes deeper and focuses on the gut microbiomes in individuals who are still in the pre-symptomatic stage. In this phase, people accumulate amyloid beta, tau, and other proteins in the brain without showing neurodegeneration, cognitive decline or any signs of it. This can last for up to two decades. Early diagnosis allows people to plan ahead, access resources and support, and begin treatments that can slow down the progression of disease. A better understanding of the future number of patients will also help to prepare health care infrastructure.
Researchers evaluated volunteers at the Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University. They selected cognitively normal people. The participants gave samples of blood, cerebrospinal liquid, stool and cerebrospinal, recorded their dietary patterns, and had PET and MRI scans.
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Altered gut bacteria could be early warning sign of Alzheimer’s
