Deleting dysfunctional cells alleviates diabetes
Researchers from UConn Health reported that removing old, dysfunctional fat cells also reduces the signs of diabetes. Researchers from UConn Health report that the discovery could lead new treatments for Type 2 Diabetes and other metabolic disorders.
Cells in your body renew themselves constantly. Older cells age and die as new cells are born. Sometimes, however, this process can go wrong. Sometimes damaged cells persist. They are called senescent and they can be a negative influence on nearby cells. The bad influence they have on neighboring cells can cause metabolic problems.
The most common metabolic disorder in the US is type 2 diabetes. According to the Centers for Disease Control and Prevention, one in ten Americans, or 34 million people, have it. Insulin resistance is a common factor in diabetes, and it’s often associated with obesity, poor diet, and lack of exercise. Ming Xu of UConn Health School of Medicine and her colleagues have found that it is also related to senescent fat cells. In the November 22 issue of Cell Metabolism, researchers report that clearing away these senescent cell seems to stop diabetes in obese mice. Ming Xu was the principal investigator of the study, with UConn Health researchers Lichao and Binsheng Xu as co-authors. Researchers said that the reduction of the negative effects on metabolism caused by fat was a significant result.
Source:
https://medicalxpress.com/news/2021-11-deleting-dysfunctional-cells-alleviates-diabetes.html
