A cocktail of rapamycin acarbose phenylbutyrate delayed aging in mice
Combinations of drugs that target different processes but overlap are a rational way to combat aging. To determine if the combination of drugs that have been shown to prolong lifespan and promote healthy aging would be more effective than individual drugs, 20-month old C57BL/6 mice and HET3 cross-breed mice were fed a cocktail diet for three months containing 14ppm Rapamycin, 1000ppm Acarbose and 1,000ppm Phenylbutyrate. Mice fed the cocktail diet showed an improved cognition and strength, as well as a decreased age-related pathology. This was compared with mice given individual drugs or a control. Mice treated with cocktail showed a consistent decrease in the severity of age-related kidney, liver, lung, and heart lesions compared to those treated with individual drugs. This suggests that the three drugs work together. The study found that the combination of three drugs previously shown to increase lifespan and health in mice can delay aging in middle-aged animals more effectively than individual drugs in the cocktail.
(c) 2022. The Author(s).
Statement of Conflict of Interest
Source:
https://pubmed.ncbi.nlm.nih.gov/35508491/
