David Sinclair on Aging – How to reset your age
It’s not all about NAD. Q&A right before the 35-minute mark. There’s a lot of epigenetics in this.
David A. Sinclair Ph.D. David A. Sinclair, Ph.D., A.O. is Professor of Genetics at Harvard Medical School and Co-Director of the Paul F. Glenn Center for the Biology of Aging. His work is known for helping to understand why we age, and how it can be slowed. He received his Ph.D. degree in Molecular Genetics from the University of New South Wales in Sydney in 1995. He was a postdoctoral research fellow at M.I.T. With Dr. Leonard Guarente, he co-discovered a cause for aging in yeast and the role of Sir2 on epigenetic changes caused by genome instability. He was recruited in 1999 to Harvard Medical School, where he teaches aging biology as well as translational medicine. His research is primarily focused around sirtuins – protein-modifying enzymes which respond to changes in NAD+ and caloric restrictions (CR). He also has interests in chromatin and energy metabolism as well as mitochondria, learning, memory, neurodegeneration and cancer. The Sinclair laboratory was the first to show that sirtuins play a role in CR and in the regulation of lifespan. The lab first identified small molecules such as resveratrol that activate SIRT1 and then studied their metabolic effects using genetic, enzyme, biophysical, and pharmacological methods. Recent studies have shown that both natural and synthetic stimulators need SIRT1 in order to exert their in vivo effect in muscle. They also identified a structure activation domain. They showed that the miscommunication between mitochondrial and nuclear genes is a major cause of age-related decline in physiological function and that relocalization chromatin factors as a response to DNA breaks could be a factor of aging.
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