The tangles of your DNA can cause you to age
New videos on the channel.
Join the Lifespan Heroes: https://lifespan.io/hero?source=X10-desc Join the Lifespan Heroes: https://lifespan.io/hero?source=X10-desc.
VV Sources, description, and more below
Each of your cells contains two or three meters worth of DNA, but this careful arrangement becomes muddled with time. This is why we age.
SOURCES AND FURTHER READS
Larson K, Yan SJ, Tsurumi A, Liu J, Zhou J, Gaur K, Guo D, Eickbush TH, Li WX. Heterochromatin promotes longevity by repressing ribosomal DNA synthesis. PLoS Genet. 8:e1002473.
Oberdoerffer P, Sinclair DA. (2007) The role nuclear architecture plays in genomic instability and aging. Nat Rev Mol Cell Biol. 8:692-702.
Pegoraro, G., Kubben, N., Wickert, U., Gohler, H., Hoffmann, K., Misteli, T. (2009) Ageing related chromatin defects via loss of the NuRD complex. Nat Cell Biol. 11:1261-1267.
Pollina EA, Brunet A. 2011 Epigenetic regulation in stem cells with ageing. Oncogene 30:3105-3126.
Source:
