The plasma NAD+ levels decline significantly with age
We would like to draw your attention today to a small-scale, recent study that looked at NAD+ in plasma and its decline with age.
Researchers compared the NAD+ metabolites in different age groups, and found that older people have significantly lower levels of NAD+ than younger people [1]. The lower levels are likely caused by an imbalance in the age-related cellular machinery between that which produces NAD+ and that which consumes it. It is not clear if this decline in NAD+ levels is due to an increased consumption or a decreased production.
There are other factors that may reduce the amount NAD+ in the plasma. These include inflammatory signaling molecules, and oxidative damage on the NAD+ molecules. Researchers also discuss CD38 as a key reason for NAD+ to decline with age and how blocking it could be a way to increase NAD+.
Source:
https://www.leafscience.org/the-plasma-nad-metabolome-is-dysregulated-during-aging/
