Chronic inflammation can cause a decrease in NAD+
With age, NAD+ (nicotinamide-adenine-dinucleotide) a key metabolite essential to a healthy and efficient metabolism declines. This phenomenon, which was previously unknown, is linked to a number of age-related illnesses and has led to the development of nutritional supplements that aim at restoring NAD+ levels. Researchers at the Buck Institute published their findings in Nature Metabolism. They identified chronic inflammation to be a major driver of NAD+ depletion. Researchers at the Buck Institute have shown that an increase in senescent (aging) cells causes NAD degradation via activation of CD38, a protein found on cell membranes inside and outside of many immune cells.
We are excited to be able to link two phenomena that have previously been associated with ageing and age-related diseases,\” said Eric Verdin MD, Buck Institute CEO and Senior Author of the paper. The fact that chronic inflammation and NAD+ decline are linked provides a holistic, systemic view of aging. And the discovery of CD38 macrophages as the mediator between the two gives a new therapeutic target.
Source:
https://medicalxpress.com/news/2020-11-chronic-inflammation-reduction-nad.html
