Human Induced pluripotent stem cells : Clinical significance and applications in neurologic diseases
The :3 can heal human body parts.
Generating human induced pluripotent (iPSC) stem cells from somatic cells by gene transfer is a new area for precision medicine. It allows for personalized cell therapy, and it encourages the development of platforms that are essential for drug discovery. iPSCs can regenerate indefinitely and differentiate into any cell type using a variety of published protocols. They retain the donor’s genome, are able to regenerate indefinitely and have the ability to differentiate into virtually any other cell type. Researchers have shown a great deal of interest in the use of iPSCs for regenerative medicine, and disease modeling. This is especially true when it comes to neurologic diseases. iPSCs or tissues derived from iPSCs can be used to treat Parkinson’s, Alzheimer’s, and spinal injuries. This review focuses on the recent progress in using human iPSCs for clinical purposes.
Stem cells are capable of self-renewal, and they can be differentiated into different tissue types. Based on their differentiation ability, these are classified into pluripotent (PSCs), embryonic stem (ESCs) and induced pluripotent (iPSCs) stem cells and multipotent (adult stem (ASCs) stem cells. PSCs (including ESCs derived directly from embryos or iPSCs derived via gene transfer) can undergo an indefinite proliferation, and then differentiate into various types of tissue depending on treatment conditions [86]. Multipotent stem cell can be obtained by tissue-derived precursors, such as umbilical cord blood or bone marrow.
Source:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732359/
