Cellular senescence is a major factor in the development of cerebral tumors
Glioblastomas, the most common malignant brain tumors in adults, are difficult to treat. They are resistant to conventional treatments, such as surgery, radiation therapy, and chemotherapy. Glioblastomas persist despite this arsenal.
Isabelle Le Roux, CNRS, and her colleagues at the Paris Brain Institute’s \”Genetics and Development of Brain Tumors\” team have published a study in Nature Communications that shows that eliminating senescent (non-dividing) cells can alter the tumor ecosystem and reduce its progression. These results provide new treatment options.
Glioblastoma is the most common brain cancer in adults. It affects between 2 and 5 people per 100,000. The incidence of this disease is higher in people aged 55 to 85, but it is on the rise in all age categories. This effect cannot be attributed solely to better diagnostic techniques, and may reflect the influence of previously unknown environmental factors.
Source:
https://medicalxpress.com/news/2023-02-cellular-senescence-plays-significant-role.html
