Oxygen restriction helps fast-aging lab mice live longer
Researchers have demonstrated for the first time that a reduced oxygen intake or \”oxygen reduction\” is associated with a longer lifespan in laboratory mice, highlighting it’s anti-aging potency. Robert Rogers, from the Massachusetts General Hospital, Boston, US, along with his colleagues, present their findings in an open-access journal PLOS Biology published on May 23rd.
In the quest to increase healthy lifespan, researchers have found a variety of chemicals and other interventions which show promising results in lab mammalian animals. For example, metformin (a drug) or dietary restrictions. Oxygen limitation has been associated with a longer lifespan for yeast, fruit flies, and nematodes. Its effects on mammals are unknown.
Rogers and his colleagues performed lab experiments on mice that were bred to show classic mammalian signs of aging in their entire bodies, while also aging more rapidly than other mice. Researchers compared mice who lived at normal oxygen levels in the atmosphere (about 21%) with mice that were moved at age 4 to an environment that had a lower oxygen content (11%, similar to what is experienced at 5,000 meters altitude).
Source:
https://medicalxpress.com/news/2023-05-oxygen-restriction-fast-aging-lab-mice.html
