Hematopoietic transfer of the anti-cancer and life-extending capabilities of a genetically engineered blood system
There is a causal relationship between the aging process and organ decay, dis-function and cancer. The EklfK74R/K74R mouse model (also known as EklfK74R/K74R) carries a mutation at the sumoylation sites of the hematopoietic KLF1/ EKLF transcription factor. This genetically engineered mice has exhibited a long lifespan, healthy traits and resistance to cancer. We show that the high anti-cancer capability of the Eklf (K74R) mice are gender-, age-and genetic background-independent. The anti-cancer ability and prolonged lifespan of Eklf mice (K74R), could be transferred by transplanting their mononuclear bone marrow cells to wild type mice. The analysis of global/targeted gene expression profiles has revealed changes in the expression of certain proteins and cellular pathway in leukocytes from the Eklf mice (K74R). These changes are in the direction of anti-cancer or anti-aging. This study shows the feasibility of creating a new hematopoietic/blood system that can be used to fight cancer and ageing.
The authors have not declared any competing interests.
Source:
https://www.biorxiv.org/content/10.1101/2023.04.21.537849v1
