Hyaluronic Acid: A key molecule for skin aging
Skin aging is multifactorial and consists of two independent and distinct mechanisms: intrinsic aging and extrinsic ageing. A high water content in youthful skin is responsible for its resilience, pliability and turgor. Moisture is lost due to daily external injuries, as well as the aging process. Hyaluronic Acid (HA) is the key molecule in skin moisture. It has a unique ability to retain water. Multiple sites are involved in the regulation of HA synthesis and deposition as well as cell and protein associations and degradation. This reflects the complexity of HA metabolic processes. Multigene families express HA receptors and enzymes which catabolize or synthesize HA. Understanding the metabolism of skin HA and its interactions with other components of skin will help to rationally modulate the moisture of skin.
Key words: hyaluronic acids, hyaluronidases (CD44), RHAMM and skin aging.
The biological process of skin aging in humans is complex and not fully understood. The result is two biologically separate processes. It is a natural process that affects skin and internal organs in the same way. Extrinsic or photoaging is caused by external factors such as ultraviolet (UV) radiation. Intrinsic aging is affected by hormonal changes, including the decrease in sex hormone production from mid-twenties onwards, and the decline of estrogens and prosgesterone during menopause. The deficiency of estrogens and androgens is known to cause collagen degradation, loss of elasticity and wrinkles in the skin.
Source:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583886/
