Japan university combats aging through transplanted pluripotent cells
The Osaka University research team concluded that a clinical study of IPS-derived corneal tissues was both safe and effective. This is further proof that cellular reprogramming using Yamanaka factors will lead to scalable therapies.
Longevity. The trial was conducted over several years, and corneal tissue derived from induced-pluripotent stem cells were used. According to the researchers, the tissue was implanted into four patients who were almost blind. None of them experienced tumorigenicity or rejection of the transplanted cell. All four patients were free from side effects a year after the transplant.
IPS cells can easily be created from any adult stem cell using Yamanaka factors – a grouping of protein transcription factors derived from four master gene. These induced cells show the important quality of pluripotency, as they can differentiate into any other cell type in the body. This is extremely useful for both research and therapy.
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Japan university tackles aging with transplanted pluripotent stem cells
