NAD+ Regulates Fat Cell Formation
The researchers concluded that NAD+ needs to be synthesized after it has been consumed in order to maintain normal cellular function. The researchers concluded that this is in line with previous research, which suggests that NAD+ depletion leads to metabolic changes and increased risk for certain diseases. This usually happens due to aging as NAD+ levels start to decline.
The research team believed that NAD+ could be connected to cellular metabolism or gene regulation. The researchers found evidence that suggests compartmentalized NAD+ production and subsequent consumption is integrated with glucose metabolism, adipogenic transcription and adipocyte differentiation as part of the differentiation process.
NAD+ synthase acts as a mediator for PARP-1-regulated transcript during differentiation of adipocytes. This links cellular metabolism with the adipogenic transcriptional process. During adipogenesis the nuclear NAD+ level falls, resulting in the induction NMNAT-2 (the cytoplasmic NAD+ synase). The increased level of NMNAT-2 reduces the available NMN, which leads to a decrease in nuclear NAD+ synthesis through NMNAT-1. This drop in NAD+ leads to a decrease in PARP-1 activity. This then results in a reduction in inhibitory ADP ribosylation levels of the adipogenic C/EBPb transcription factor. C/EBPb is less ADP-ribosylated, which means it can bind to its target genes and promote differentiation of preadipocytes. A decrease in NAD+ promotes the conversion of preadipocytes into adipocytes.
Source:
https://www.leafscience.org/nad-regulates-fat/
