The neurology-related proteins biomarkers and cognitive ability in older age are related
It is crucial to identify biological correlates for late-life cognitive function in order to develop biomarkers and treatments that can help to reduce age-related cognitive decline. We investigated the association between the plasma levels of 90 neurology related proteins (Olink(r), Proteomics), and general fluid cognitive abilities in the Lothian Birth Cohorts 1936 (LBC1936; N = 798), Lothian Birth Cohorts 1921 (LBC1921,N = 165), as well as the INTERVAL BioResources (N = 4451). In the LBC1936 22 of the proteins showed a significant association with general fluid cognition (b between 0.11 and 0.17). The association between general fluid cognitive abilities and 10 of these proteins was partially mediated by MRI-measured total brain volume. In a subsample matched by age of INTERVAL the effect sizes were smaller but still in the same direction. In some cases, plasma levels of a variety of neurology-related protein are related to fluid cognitive abilities in later life.
Source:
https://www.nature.com/articles/s41467-019-14161-7
