Nucleophagy slows aging, preserves germline immortality and delays Aging
The role of these changes, and their underlying mechanisms, are still not well understood. The authors found that the nuclear membrane anchor protein ANC-1, in worms and its equivalent nesprin-1, and nesprin-2, in mammals, promotes nuclear component degradation to limit nucleolar function and size in a mechanism of soma longevity.
Source:
https://www.nature.com/articles/s43587-022-00327-4
