Interview with Professor George Church
We had the chance to interview Professor George Church recently, a geneticist and expert in rejuvenation who we’ve previously interviewed. Rejuvenate Bio will launch a clinical study to test a rejuvenation treatment on dogs in the fall.
In your paper on genome editing at large scale, you discussed manipulating transposable endogenous elements using dead Cas9 base editor. Andrei Gudkov discussed the super mutagenic phenotype resulting from the expression LINE1 reverse transcriptionase at Ending Age Related Diseases. In this context, Gudkov mentioned that the retrobiome, as he called it, could be the primary driver of all forms of cellular injury, which are then improperly addressed because of immunosenescence. Do you agree with his view on the role of LINEs or SINEs as a factor in aging. Why not?
Yes. This is why we investigated the technology for editing repeats. This is now being extended to germline engineering for repeats.
Source:
https://www.leafscience.org/an-interview-with-professor-george-church/
