Skeletal Aging Can Be Reduced by Rejuvenation Mesenchymal stem cells
The advanced age of a person is a risk factor that can lead to many debilitating and chronic skeletal conditions, including osteoporosis. Mesenchymal cells exhibit a variety of aging characteristics, including senescence and intrinsic loss of regeneration potential. Secretory factors also exacerbate the inflammation microenvironment. This review explores the new concepts of MSC senescence such as DNA damage, oxidative stress and mitochondrial dysfunction. Senescent MSCs can aggravate local inflammation and disrupt bone remodeling, bone-fat balance as well as bone-fat metabolism, contributing to age-related bone disease progression. Different rejuvenation approaches to target senescent senescent cells could be a promising paradigm for restoring skeletal aging.
Source:
https://www.mdpi.com/2073-4409/12/7/998
