Senescent Cells and Cataract Development
Researchers have recently explored the senescence related proteins and their interactions with cataracts. Cataracts are a major cause of blindness and visual impairment in older adults.
The clouding of the eye’s lens is a sign of cataracts, and it can lead to impaired vision. Cataracts usually develop slowly, and they can affect both eyes simultaneously. Cataract symptoms include blurred or double vision, halos surrounding light, difficulty seeing at night, and faded colors.
These researchers are analyzing proteins and their interaction to gain a better understanding of the condition. They show that several biomarkers linked with aging increase during cataract formation. When p53 (a biomarker that is well known for indicating the presence of senescent cell) and transforming growth-factor-beta1(TGF-b1) are present in large amounts, they tend to increase. This research shows that the number of senescent (dead) cells increases during the development of cataracts.
Source:
https://www.leafscience.org/senescent-cells-and-cataract-development/
