NAD+ can restore age-related muscle deterioration
As we age, our muscles become weaker, resulting in frailty, and even physical disability. This is not only a problem for the individual but also impacts on the public healthcare system. But despite research into the biomarkers and biological processes that define muscle ageing, the causes have yet to be identified.
A team of EPFL School of Life Sciences scientists, led by Johan Auwerx, has now taken a new look at this issue. They examined the similarities between degenerative muscle disease and muscle aging. The researchers discovered that protein aggregates deposit in the skeletal muscle during natural aging. They also found that blocking these can help prevent the negative effects of muscle aging. Cell Reports published the study.
Auwerx explains that during age-associated muscle disease, such as inclusion bodies myositis, our cells struggle with maintaining correct protein folding. This causes misfolded protein to precipitate, forming toxic proteins aggregates in the muscles. The most prominent component in these protein aggregates, like the amyloid in Alzheimer’s patients’ brains, is beta-amyloid.
Source:
https://medicalxpress.com/news/2021-01-nad-age-related-muscle-deterioration.html
