Resveratrol, Polyphenols and Genomic Stability
Researchers have found that resveratrol (a chemical in red wine) contributes to genomic stabilization by reducing DNA double-strand breakage and prolonging lifespan in genetically altered mice who are susceptible to carcinogenic mutations.
DSBs, genomic instability and DSBs
Genomic instability is one of the hallmarks associated with aging. It is characterized by frequent genetic mutations and has been linked to cancer for a long time [2]. This study’s authors state that the erroneous repairs of DNA double-strand break (DSB) is one of the major causes. Pre-cancerous cell lines have a high number of DSBs, and DNA lesions from unrepairable DSBs increase over time in both organisms and cultured cells. The degradation of DNA repair systems in old cells is one of the potential culprits.
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