Metformin and Rapamycin Rejuvenate stem cells in Mice
Metformin should only be taken by people with diabetes. Rapamycin combined with Metformin reduced each other’s side effects in a combination test. Here is another combination test that shows the effect of stem cells in the intestine.
Researchers have demonstrated in a study published in Aging cell that two promising antiaging agents, the anti-diabetic drug metformin and the antibiotic rapamycin, reverse the aging of a population a stem cells in the intestine [1].
The gastrointestinal system is more susceptible to problems in older people [2]. A major risk factor of cancer, including colorectal, is ageing. It is therefore necessary to develop new therapeutic approaches for rejuvenating the aging intestine.
Stem cells maintain the function and structure the intestinal epithelium (a single layer of cells that lines the small and large intestines and colon). Intestinal stem cell division is continuous, resulting in several types of progenitor cellular types.
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