Scientists Discover How to Reverse Aging
Scientists have increased the lifespan of animal and first studies describe how we could reverse aging. How could we possibly reverse aging one day?
Subscribe for more awesome biomedical research: https://bit.ly/2SRMqhC
IG: instagram.com/clemens.steinek.
Twitter: https://twitter.com/CSteinek.
Scientists discovered in the 1970s that cells can only grow for so many days (the Hayflick limit) in the lab. Over time, scientists have discovered the so-called hallmarks for aging. These hallmarks of ageing govern the way our cells age, and we can try to \”reverse\” aging by slowing them down.
Mutation is the first sign of aging. Mutations can be acquired by UV radiation, certain chemicals or cell division. Cell division also causes a second sign of aging, telomere degradation. Moreover, as the quality check no longer works properly, our mitochondria begin to function less.
Epigenetics is closely linked with the hallmarks of ageing. We have mechanisms that regulate gene activity (DNA methylation and histone modifications). Epigenetics not only affects aging but also the development of embryonic cells into our cells. For example, epigenetic dysfunction is associated with the loss of mitochondria. As we age, three epigenetic modifications, namely H4K16 trimethylation, H3K4 acetylation or H4K20 methylation accumulate. It’s true that epigenetics can be reversed… but is it possible to reverse aging as well?
It has been proven that diets can slow down aging (and even reverse it to a certain degree). The DNA of the cells is also less damaged and there are higher levels in \”young\” cells. If we restrict our caloric intake, the activity of mitochondria will also increase. Diets can also affect the production of sirtuins, which increases lifespan and reverses aging. It has been demonstrated that different compounds (such as remodelin and NMN) can improve the epigenetic environment, which could have an impact on reversing ageing. Exercise can also help reverse aging, as it increases the activity of mitochondria. Mediation and a reduction in stress can also help increase the length of telomeres, which could reverse aging. Let’s see how this goes.
0:00-0:46 Intro.
Hallmarks of Ageing.
3:53-6:38 Epigenetics Controls Genes.
6:38-8.45 Reversing Ageing: What is known?
8:45-11.25 Reversing Ageing through Diet & Sports.
11:25-12:13 My Opinion.
References:
https://journals.plos.org/plosone/article/file?id=10.1371/jo…=printable.
https://reader.elsevier.com/reader/sd/pii/S0092867416310005?…0210202615
https://www.frontiersin.org/articles/10.3389/fendo.2018.00258/full#B37
https://www.frontiersin.org/articles/10.3389/fendo.2018.00258/full.
https://www.sciencedirect.com/science/article/pii/S0092867413006454#bib134
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104429/
https://journals.plos.org/plosone/article/file?id=10.1371/jo…=printable.
https://reader.elsevier.com/reader/sd/pii/S0092867413015213?…0210203919
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402507/
https://www.mdpi.com/2072-6643/12/4/1194
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361673/
https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.
Source:
