The Molecular Switch reverses chronic inflammation and aging
Scientists at the University of California have identified a molecular switch that controls the immune system, which is responsible for chronic inflammatory conditions in the body. The findings, published in Cell Metabolism, may lead to the development of new methods to reverse or stop age-related diseases such as Alzheimer’s, Parkinson’s, and diabetes.
My lab is interested in the reversibility and reversibility. Danica Chen, senior author, associate professor at UC Berkeley, is an expert on metabolic biology, nutritional science, and toxicology. In the past, we have shown that stem cells aged over 30 years old can be rejuvenated. We are now asking, to what extent is aging reversible? We are looking at physiological conditions like insulin resistance and inflammation that have been linked to aging-related diseases and degeneration.\”
Deacetylation can be used to switch off a large collection of NLRP3 immune proteins that are responsible for sensing threats and triggering an inflammatory response. The overactivation of NLRP3 immune proteins is associated with a variety of chronic diseases such as diabetes, cancer, dementia and multiple sclerosis. This study suggests that drugs targeting the deacetylation of these NLRP3 immunoproteins could help prevent or treat age-related conditions.
Source:
https://www.worldhealth.net/news/molecular-switch-reverses-chronic-inflammation-aging/
