A pilot randomised clinical trial reveals the potential to reverse epigenetic age by modifying diet and lifestyle.
This article claims that dietary and lifestyle changes can reverse a 3-year epigenetic clock in only 8 weeks. You can also find a list with supplements:
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The aging population and the associated healthcare costs have sparked interest in manipulating biological aging to extend healthspan. We report here on a randomized, controlled clinical study conducted with 43 healthy male adults aged 50-72. The 8-week program included dietary, sleep, relaxation, exercise, and guidance on relaxation, as well as supplemental phytonutrients and probiotics. The control group did not receive any intervention. The Illumina Methylation Epic Array was used to analyze DNA methylation in saliva samples. DNAmAge, calculated by the Horvath DNAmAge clock 2013, was then calculated. Diet and lifestyle treatments were associated with a decrease of 3.23 years in DNAmAge when compared to controls (p=0.018). DNAmAge decreased an average of 1.96 years for those in the treatment groups by the end of program, compared with the same individuals starting the program. There was a strong tendency towards significance (p=0.066). Changes in blood biomarkers were significant for mean serum 5-methyltetrahydrofolate (+15%, p=0.004) and mean triglycerides (-25%, p=0.009). This is the first randomized-controlled study that we are aware of to suggest specific dietary and lifestyle interventions can reverse Horvath DNAmAge 2013 epigenetic aging among healthy adult males. These findings need to be confirmed by larger-scale, longer-term clinical trials as well as research in other human populations.
Keywords: epigenetic, DNA methylation and aging.
The oldest age group is at the highest risk for mental and physical impairment, as well as many non-communicable illnesses such as cancer, neurodegeneration and type 2 diabetes. Our rapidly aging population poses a number of health-related challenges, including economic and social ones. These affect people, their families, the health system, and economies. Considered in isolation, delaying the aging process by 2.2 (and extending healthspan as a result) could save $7 trillion within fifty years. The broad approach has been identified as a better investment than spending on specific diseases. If interventions are identified that can extend healthspan, even modestly, the benefits to public health and healthcare will be significant.
Source:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064200/?tool=pubmed
