Human Skeletal Muscle Aging & Mutagenesis
This is an article that I wrote.
Study on the aging of human skeletal muscles, mutagenesis and the role #satellite cell
The interplay between stem cells’ intrinsic and extrinsic components will help to improve cell therapies that can restore tissue homeostasis in older people and enhance muscle repair.
The human body is affected by aging in multiple ways. Human aging can lead to a decrease in the function of skeletal muscles (SkM), as well as a reduction of the number of satellite cells (SCs), which are resident stem cells. To study the relationship between SC aging, and muscle impairment in healthy individuals (aged 21-78), the whole genomes of SC clones from the leg muscle vastus latis were analyzed. The rapid increase in SCs in healthy adult muscles is consistent with an accumulation rate of thirteen somatic mutations on each genome per year. SkM-expressed gene mutations are rare because they’re protected. As mutations in exons or promoters increase in frequency, genes that are involved in SC function and muscle activity become targeted, resulting in aging. The exons of an RNA transcription or DNA that encodes it are the sections which are translated to protein. The synthesis of molecules is what makes up proteins.
Source:
http://radicalsciencenews.org/human-skeletal-muscle-aging-and-mutagenesis/
