The senescent macrophages are eliminated by senolytic removal, restoring the muscle stem cells function in severely dystrophic muscles
In fact, senescent macrophages also express the senescence markers p16 (Ink4a), and b galactosidase(b-gal), which promote inflammation in diseased tissue [25,26]. In our previous studies, we have shown that dystrophic muscles in mdx/utr (-/-) mouse models exhibit increased cellular ageing [3]. However, it was not known whether macrophages would also develop cellular ageing and promote senescence-associated phenotypes. In order to solve these puzzles, we examined the mdx/utr (-/-) mouse further.
When skeletal muscles are injured, immune cells become activated and work in coordination with muscle stem cells to promote muscle regeneration. Studies with severely diseased muscle demonstrate that immune cells are able to become dominantly active and induce increased fatty accumulation and fibrosis, while simultaneously repressing the proliferation and function or muscle stem cells. In severely dystrophic muscles, our current results reveal that macrophages interact with MPCs in a similar way. They repress the MPCs’ function. SASPs can have a profound effect on normal cell growth and function when senescent or aged cells accumulate.
Source:
https://www.aging-us.com/article/204275/text
