The aging of skeletal stem cells can interfere with healing, and even promote inflammation.
Researchers at Stanford Institute for Stem Cell Biology and Regenerative Medicine discovered that changes in aging stem cells could be a cause for poor fracture healing, osteoporosis and other blood disorders. They also found that generalized inflammation and ageing (sometimes called \”inflammaging\”) can affect cells and systems all over the body. Researchers are working to find ways to reinvigorate the aging stem cells so they can start acting like younger ones, possibly reversing this change.
Charles Chan, PhD is a member of this institute and assistant professor at the Department of Surgery and Plastic and Reconstructive Surgery and Immunology. If skeletal stem cell performance is not optimal, it can lead to many of the diseases that are common in older adults.
The research was published in Nature. The paper is co-authored by Chan and Michael Longaker. Longaker is Dean P. and Louise Mitchell professor in the School of Medicine and member of the Institute for Stem Cell Biology and Regenerative Medicine. Thomas Ambrosi is a postdoctoral researcher and co-first author with Owen Marecic, MD.
Source:
https://medicalxpress.com/news/2021-08-aged-skeletal-stem-cells-inflamm-aging.html
