Does a breached blood-brain barrier cause seizures in AD?
Scientists led by Daniela K. Kaufer of the University of California Berkeley and Alon F. Friedman of the Ben-Gurion University of the Nevev in Beer-Sheva (Israel) report in two papers published in Science Translational Medicine on December 4, that age-related cracks allow serum protein albumin to enter the brain where it activates TGFb receptors and over-excites neuronal networks. This impairs cognition. The occurrence of breaches was correlated with a localized slowing in cortical activity among epilepsy patients, Alzheimer’s patients, and mouse models of AD. These activity changes, called paroxysmal slower-wave events in epilepsy patients, are correlated with cognitive decline and interspersed by seizures.
Source:
https://www.alzforum.org/news/research-news/does-breached-blood-brain-barrier-cause-seizures-ad
