DNA Damage Causes Epigenetic Alterations
Recently, a team of researchers including Dr. David Sinclair made a study available in preprint form before peer review and publication by the journal Cell.
Double-strand breaks and DNA damage
The two primary signs of aging include genomic instability (damage to DNA) and epigenetic changes, which are changes in gene expression caused by aging. These are harmful for normal cell function.
Source:
https://www.leafscience.org/dna-damage-leads-to-epigenetic-alterations/