Understanding neurodevelopment and diseases could be improved by understanding the sites in the brain that RNA is edited.
Mount Sinai researchers cataloged thousands in the brain, where RNA is altered throughout the lifespan of the human in a process called adenosine to inosine (A-to I) editing. This offers important new avenues in understanding the cellular mechanisms and molecular mechanisms that influence brain development.
The team published a study in Cell Reports that described how the rate at which RNA editing occurs in the brain increases with age. This has implications for determining the pathology associated with altered A-to I editing in a variety of neurodevelopmental disorders and aging disorders.
Our work provides nuanced and accurate insight into the contribution of RNA modification by A-to I editing during brain development,\” said senior author Michael Breen Ph.D. Assistant Professor of Psychiatry and Genetics and Genomic Sciences at the Icahn School of Medicine Mount Sinai and a member of Seaver Center for Autism Research and Treatment.
Source:
https://medicalxpress.com/news/2022-11-sites-brain-rna-neurodevelopment-disease.html
