RbAp48 and Osteocalcin play a crucial role in age-related memory loss
The protein RbAp48, in conjunction with osteocalcin, helps to maintain memory as we age.
Scientists at Columbia University demonstrated in a recent study that the protein RbAp48 interacts crucially with osteocalcin, which helps preserve memory. The protein, present in both mice and people, decreases with age. This contributes to age-related loss of memory [1].
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It is important to understand the exact molecular mechanisms behind age-related memory decline in order to develop effective therapeutic interventions. Previous studies have shown that RbAp48/Rbbp4 histone-binding proteins are a major molecular factor in Age-Related memory loss. We found that RbAp48 regulates the expression of BDNF, GPR158, and other proteins critical to osteocalcin signaling (OCN), in the mouse hippocampus. We demonstrate that blocking RbAp48 causes impairments in discrimination memories and inhibits OCN’s cognitive benefits. In turn, disruptions in OCN/GPR158 signals lead to the downregulation RbAp48, which mimics the age-related memory deficits. We show that activating the OCN/GPR158 signaling pathway increases expression of RbAp48 and reverses age-related memory deficits.
Source:
https://www.leafscience.org/rbap48-and-osteocalcin-play-a-crucial-role-in-age-related-memory-loss/
