Unexpected results achieved with simultaneous modification of insulin and rapamycin signalling pathways in nematode worms

Nematode Worms Livespan Increased by 500%

Caenorhabditis is a nematode that is often used in research on longevity due to its genetic similarity with humans and extremely short life spans (often less than four weeks). Researchers have found that modifying the insulin and rapamycin pathways of these worms can increase their lifespan by 100% or 30%. The success of the previous research prompted a question: what would happen if the two pathways were altered simultaneously?

Photo of an adult Caenorhabditis hermaphrodite. Scale bar, 100 mm. Credit: ResearchGate, Nobuyuki Hamada.

Source:
https://www.regenerativemedicinedaily.com/LifespanIncreaseAchievedinNematodeWorms

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