What you need to Know about SIRT6
Sirt6 activators are available on the market but I question their worth because we haven’t heard anything about any significant results.
SPONSOR: Longevity. Technology — https://www.longevity.technology/?utm_source=SSS&utm_medium=…aign=Sirt6
Sirtuins, which are highly conserved proteins, are involved in many important cellular processes including DNA repair and metabolism. They also play a role in circadian rhythms. The mammalian sirtuins (SIRT1-7) are a family of proteins that carry out NAD+-dependent protein deacylation and mono-ADP-ribosylation. These modifications can affect the stability of proteins, their localisation in a cell, and their activity.
Interest in sirtuins grew as late 1990s, when it was discovered that yeasts lived 30% longer with an extra copy of the yeast sirtuin Sir2. Overexpression of SIRT1 does not extend lifespan in mice. However, SIRT6 overexpression does. SIRT6 is now referred to by the term longevity sirtuin. There are some differences between the mouse strains and based on sex. In the rest of the video we will talk about what you should know about SIRT6, including its proposed cellular functions, its association with longevity, and how SIRT6 could be used as a future therapeutic tool.
TIMESTAMPS:
Intro — 00:00
Sirtuins – 00:45
SIRT1, SIRT6 & Longevity — 03:00
SIRT6 DNA Damage — 08:30
Activating SIRT6 – 09:50
Additional thoughts — 11 : 45
#longevity #science #latestresearch #TSSS
REFERENCES:
Roichman, A., Elhanati, S., Aon, M.A. et. al. SIRT6’s restoration of energy homeostasis extends healthy life span. Nat Commun 12, 3208 (2021). https://doi.org/10.1038/s41467-021-23545-7
Regulation of SIRT6 protein levels by nutrient availability — https://doi.org/10.1016/j.febslet.2008.01.019
Regulation of SIRT1 protein levels by nutrient availability — https://doi.org/10.1016/j.febslet.2008.06.005
Kanfi, Y., Naiman, S., Amir, G. et al. The sirtuin, SIRT6, regulates the lifespan of male mice. Nature 483218-221 (2011). https://doi.org/10.1038/nature10815
Sirtuin activators and inhibitors: Promises, achievements, and challenges — https://doi.org/10.1016/j.pharmthera.2018.03.004
SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species — https://doi.org/10.1016/j.cell.2019.03.043
Huang, Z., Zhao, J., Deng, W. et al. Identification of an allosteric SIRT6 activator that is cellularly active. Nat Chem Biol 14 (2018) 1118-1126. https://doi.org/10.1038/s41589-018-0150-0
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